2/20/2023 0 Comments Beyond skin deep![]() ![]() Disturbed sleep has been reported by 80% patients with AD 11.Severe or unbearable itch was reported by 61% of patients, and 42% reported itching for 18 hours a day or more 10ĪD can also have a profound impact on the quality of life of patients:.Among patients with moderate-to-severe disease, 86% have reported itch every day 10.Itch leads to scratching and painful skin, and is the cause of significant patient burden: Regardless of race or ethnicity, itch is the cardinal symptom of atopic dermatitis. 6-9 Pigmentary changes in the skin can also occur in patients with skin of color following inflammation due to AD, which can be highly distressing. In patients with lighter skin types, inflammation due to AD is usually a pink or red shade 1,3-5 while in patients with skin of color or darker skin types (a special topic at this year’s AAD meeting), inflammation can appear purple, light brown or ashen grey, and typical signs can include scattered hard bumps on the skin, particularly around the follicles. Typically, AD presents as inflamed, dry/flaky skin with skin thickening, and lesions that can ooze and crust. To mark the 2022 American Academy of Dermatology (AAD) Annual Meeting, which starts this week, here we review some of the key characteristics of the disease and explore some of these newer therapeutic approaches that may help patients ditch the itch and clear their skin for good.ĪD is a complex disease, with a chronic and flaring course, caused by multiple interrelated factors including immune dysregulation, skin barrier dysfunction, genetic mutations, and environmental triggers. In recent years, much attention has been directed at the development of novel therapies that target elements of the immune system that are overactive in AD. While topical therapies such as emollients and steroid creams are the mainstay of therapy for all patients with AD, 2 treatment options have been much more limited for patients with moderate-to-severe disease, who do not respond to or cannot use topical therapy. 1 It is an autoimmune condition characterized by intensely itchy skin lesions. Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disease in the world, with a lifetime prevalence of up to 20%.
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